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目的和方法：在甘油致大鼠急性肾功能衰竭（ＡＲＦ）模型上，观察了硝苯吡啶对ＡＲＦ大鼠肾功能及内源性内皮素（ＥＴ）释放的影响。结果：ＡＲＦ大鼠肾皮质钙含量及血浆ＥＴ（ＰＥＴ）水平明显升高，肾功能严重受损，肾小管ＥＴ免疫反应阳性颗粒显著增多；而硝苯吡啶则使ＡＲＦ大鼠肾皮质钙含量及ＰＥＴ水平明显降低，肾小管ＥＴ免疫反应阳性颗粒明显减少，肾功能得到改善。结论：硝苯吡啶改善肾功能的作用可能与其抑制ＥＴ的合成与释放以及拮抗ＥＴ的生物学作用有关。
OBJECTIVE: To observe the effects of nifedipine on the renal function and the release of endothelin (ET) in rats with acute renal failure (ARF) induced by glycerol. Results: The renal cortical calcium content and plasma ET (PET) level were significantly increased in ARF rats, the renal function was severely impaired, and the tubular immunoreactive granules in renal tubules were significantly increased. However, nifedipine caused renal calcification in ARF rats, PET significantly reduced the level of tubule ET immunoreactive particles significantly reduced, renal function improved. Conclusion: The effect of nifedipine on renal function may be related to the inhibition of the synthesis and release of ET and the antagonism of the biological function of ET.