The role of CTLA4-Ig in a mouse model against allergic asthma

来源 :Chinese Medical Journal | 被引量 : 0次 | 上传用户:moodlysea
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective To investigate CTLA4-Ig’s potential role in therapy for allergic asthma by blocking B7/CD28 interactions with cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig). Methods We divided BALB/C mice into the three groups: Sham/Sham (control), ovalbumin (OVA)/OVA and mCTLA4-Ig. Blood, bronchoalveolar lavage, histology and determination of cytokines were performed 24 hours after airway challenge. Results In the OVA/OVA group, the number of cells, the percentage of inflamed cells and the level of IL-4 in BALF were increased. Airways in our murine model for allergic asthma underwent pathological changes, which were significantly reduced after treatment with mCTLA4-Ig. Conclusion Blockage of co-stimulation with mCTLA4-Ig can inhibit allergy-specific response of T cells, and asthmatic response as well. Objective To investigate CTLA4-Ig’s potential role in therapy for allergic asthma by blocking B7 / CD28 interactions with cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig). Methods We divided BALB / C mice into the three groups: Sham / Sham ), ovalbumin (OVA) / OVA and mCTLA4-Ig. Blood, bronchoalveolar lavage, histology and determination of cytokines were performed 24 hours after airway challenge. Results In the OVA / OVA group, the number of cells, the percentage of inflamed cells and The levels of IL-4 in BALF were increased. Airways in our murine model for allergic asthma underwent pathological changes, which were significantly reduced after treatment with mCTLA4-Ig. Conclusion Blockage of co-stimulation with mCTLA4-Ig can inhibit allergy-specific response of T cells, and asthmatic response as well.
其他文献
Objective To evaluate the potential role of insulin-like growth factor-1 receptor mRNA(IGF-IR mRNA) in the onset and development of retinopathy in diabetic rats
Objective To observe the effects of Dexamethasone (Dex), a synthetic glucocorticoid, on glucocorticoid receptor expression in the human ovarian carcinoma cell l
Objectives To study the relationship between serum levels of hyaluronic acid (HA), type Ⅲ procollagen (PCⅢ), laminin (LN), type Ⅳ collagen (Ⅳ-C) and hepati
Objective To investigate the effects of the combination of octreotide and aspirin on the growth of gastric cancer. Methods Proliferation of gastric cancer cel
Objective To identify the characteristics of and evaluate surgical impact on idiopathic macular hole (IMH) by using an optical coherence tomography (OCT) scanne
首次从蝉翼藤(Securidaca inappendiculata Hassk)茎乙醇提取物的乙酸乙酯部分分离到两个新的具有抗氧化作用的(口山)酮类化合物securixanthone C (1) 和 securixanthone D (
Objective To study the effects of vitamin E on the proliferation and collagen synthesis of rat hepatic stellate cells treated with interleukin-2 (IL-2 ) or tumo
Objective To investigate the relationships between the polymorphisms of estrogen receptor (ER) gene, bone mineral density (BMD) and bone biochemical markers in
Objective To explore the factors which induce differentiation of embryonic neural stem cells. Methods Rat embryonic neural stem cells were co-cultured with ne
Objectives To investigate the effect of rhein on endothelial plasminogen activator inhibitor-1 (PAI-1) mRNA expression and protein production induced by transfo