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我们结合胃癌普查,采用单向免疫扩散法进行了胃液分泌性免疫球蛋白A(SIgA)的定量测定。在受检490例中,各项检查结果正常者116例,SIgA浓度均不高于18.5mg％。我们即以此值作为SIgA正常值之上限。胃癌组22例中的5例和胃良性疾患组352例中的10例,SIgA高于18.5mg％。对此15例,1年后经纤维胃镜和活检复查,并随访二年,最后确诊5例胃癌,3例胃液脱落细胞核异质,3例胃腺体肠化生,其余均有不同程度的胃炎。上述结果表明,胃液SIgA超过18.5mg％者应仔细检查和随访;胃液SIgA测定在胃癌诊断,特别是早期诊断上可能具有弥补胃液脱落细胞学检查和胃肠X线检查的不足的实用价值。
Combined with gastric cancer screening, we used a one-way immunodiffusion method for the quantitative determination of gastric secretory immunoglobulin A (SIgA). Among the 490 cases examined, 116 were normal in all examinations, and the SIgA concentration was not higher than 18.5 mg%. We use this value as the upper limit of the normal value of SIgA. Of the 22 cases in 22 cases of gastric cancer and 10 cases in 352 cases of benign disease, SIgA was higher than 18.5 mg%. In this case, 15 cases were reviewed by fiberoptic gastroscopy and biopsy 1 year later and followed up for 2 years. Finally, 5 cases of gastric cancer were diagnosed, 3 cases of gastric exfoliated nuclei were heterogeneous, 3 cases of intestinal metaplasia of the stomach gland, and others had different degrees of gastritis. . The above results showed that gastric fluid SIgA more than 18.5mg% should be carefully examined and followed up; gastric fluid SIgA determination in the diagnosis of gastric cancer, especially in early diagnosis may have to make up for the lack of gastric cytology and gastrointestinal X-ray examination of the practical value.