磷脂酶A2(PLA2)是一类能水解磷脂Sn-2位脂键的酶,也是生物化学、基因工程和药理学研究的热点酶类。近几年来一个重要发现就是某些型别PLA2具有抗菌功能,研究得最早且最多的是血小板型PLA2,它主要对G+菌具有强的抗菌活性,在宿主防御细菌感染中发挥重要作用。现就血小板型PLA2抗菌活性的研究进展作一综述。 Phospholipase A2 (PLA2) is a class of enzymes that hydrolyze the lipid bonds of Sn-2 phospholipids and is also a hot enzyme in biochemistry, genetic engineering and pharmacology. In recent years, an important discovery is that some PLA2s have antimicrobial activity. The earliest and most studied PLA2 is platelet-type PLA2. It mainly has strong antibacterial activity against G + bacteria and plays an important role in host defense against bacterial infection. The research progress of antimicrobial activity of platelet PLA2 is reviewed.