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[目的]探讨新发涂阳肺结核病人治疗失败的影响因素,为提高治疗效果提供依据。[方法]对1992~2007年在利津县疾病预防控制中心登记的新发涂阳肺结核患者1405例进行调查分析。[结果]1405例病人中,未治愈者420例,治愈者985例。与新发涂阳肺结核病人治疗失败有关联的因素有年龄、职业、合并症、肺部空洞性病灶、咯血、胸闷、病变部位多少、不规则服药、体重指数、劳动疲乏、经济收入和生活负性事件。其中年龄越大、不消瘦和经济收入越高能够减少初治失败,其他9个因素能够增加初治失败的几率。[结论]规范服药、加强营养、治疗合并症是提高新发涂阳肺结核治愈率的关键。
[Objective] To explore the influencing factors of failure of newly-developed smear-positive pulmonary tuberculosis patients and provide the basis for improving the therapeutic effect. [Method] A total of 1405 new smear-positive pulmonary tuberculosis patients registered in Lijin County Center for Disease Control and Prevention from 1992 to 2007 were investigated. [Results] Of the 1405 patients, 420 were not cured and 985 were cured. Factors related to the failure of treatment of new smear-positive pulmonary tuberculosis patients were age, occupation, comorbidities, emphysematous lung disease, hemoptysis, chest tightness, lesion location, irregular medication, body mass index, fatigue, income and living negative Sexual events. Among them, the older, less weight-loss and higher economic income can reduce the failure of initial treatment, and the other nine factors can increase the probability of failure of initial treatment. [Conclusion] Regulating medication, strengthening nutrition and treating comorbidities are the keys to improve the cure rate of smear positive pulmonary tuberculosis.