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本文在昆明种小鼠吸入不同浓度（28，67，100mg／M3）烹调油烟（COF）的情况下，观察小鼠骨髓细胞染色体畸变率和嗜多染红细胞（PCE）微核率。实验结果显示，吸入COF各剂量组小鼠骨髓细胞染色体畸变率和微核率均随COF浓度上升而增高（P＜0．05），且呈剂量反应关系，两率相关系数为0．88，表明COF进入体内后具有一定的体细胞诱变活性。
In this study, we observed the chromosome aberration rate and micronuclei of polychromatic erythrocytes (PCE) of mouse bone marrow cells in Kunming mice with different concentrations (28, 67 and 100 mg / m3) of cooking fumes (COF). The experimental results showed that the chromosome aberration rate and micronucleus rate of bone marrow cells in COF groups increased with the increase of COF concentration (P <0.05), and showed a dose-response relationship, the correlation coefficient of the two rates was 0.88, COF into the body after that certain degree of somatic mutagenic activity.