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Objective:The aim of this study was to explore the diagnostic value of multi-slice computer tomography (MSCT) in solitary pulmonary nodule (SPN). Methods:Contrastive analysis of the dif erences of CT signs between benign and malig-nant SPN. Results:The typical sign of pleural indentation was a reliable sign for lung cancers. Vacuole sign suggested lung cancer highly. Blood vessels cluster involving the vein alone had big opportunity to lung cancer. Type I tumor-bronchial relation was the most common relation in lung cancers. Type V tumor-bronchial relation was the most common relation in benign SPN. Conclusion:MSCT had a very high diagnostic value in SPN.