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[目的]探讨乳腺癌中HER-2基因的表达及其与预后的相关性.[方法]应用免疫组织化学法观察73例乳腺癌中HER-2基因的表达情况,对61例进行随访,观察预后.[结果]在24例浸润性导管癌(25/43例)、12例浸润性小叶癌(12/30例)中HER-2基因表达均呈阳性.HER-2在乳腺癌中的表达与肿瘤大小无相关性(P>0.05),而与淋巴结转移有关联(P<0.05).对61例乳腺癌患者随访结果见,HER-2基因表达呈阳性者死亡率显著高于阴性者(P<0.01).[结论]HER-2表达与乳腺癌患者预后密切相关.
[Objective] To investigate the expression of HER-2 gene in breast cancer and its correlation with prognosis. [Methods] The expression of HER-2 gene in 73 cases of breast cancer was observed by immunohistochemical staining and 61 cases were followed up Prognosis. [Results] HER-2 gene expression was positive in 24 invasive ductal carcinomas (25/43 cases) and 12 cases of invasive lobular carcinoma (12/30 cases) .Expression of HER-2 in breast cancer (P <0.05), but not with tumor size (P> 0.05), but with lymph node metastasis (P <0.05) .Among 61 patients with breast cancer, the mortality of HER-2 gene was significantly higher than that of negative P <0.01). [Conclusion] The expression of HER-2 is closely related to the prognosis of breast cancer patients.