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本文观察54例ANLL患者的造血与免疫功能的关系。其中45例进行了T细胞及其亚群测定,结果ES与T_u细胞显著低于正常而T_r细胞显著增高;在治疗过程中,T细胞亚群的动态变化提示与患者疗效反应有关,经治疗后ES与T_u细胞增高而T_r细胞降低者预后较好。24例初治患者骨髓进行了体外细胞培养,其中21例不能产生正常细胞集落。41例PEG沉淀物测定指数显著高于正常,提示有循环免疫复合物存在。本文对白血病细胞抗原、T细胞亚群及造血间的关系进行了讨论。
This article observes 54 cases of ANLL patients hematopoietic and immune function. Among 45 cases, T cells and their subpopulations were determined. The results showed that ES and T_u cells were significantly lower than those in normal T_r cells and T_r cells were significantly increased. The dynamic changes of T cell subsets in the course of treatment were related to the response of patients. After treatment ES and T_u cells increased T_r cells decreased prognosis is better. Twenty-four patients with newly diagnosed bone marrow cells were cultured in vitro, of which 21 cases failed to produce normal cell colonies. 41 cases of PEG precipitate determination index was significantly higher than normal, suggesting the presence of circulating immune complexes. This article discusses the relationship between leukemic cell antigens, T cell subsets, and hematopoiesis.