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背景:应用抗骨痛注射液治疗关节肿痛经过对中药的多次筛选及10余年的临床观察,在消除关节肿痛、颈椎病、骨关节病症状及体征方面效果较为突出。为进一步研究抗骨痛对关节肿痛、颈椎病、骨关节病治疗作用的机制,作者做了动物实验观察。目的:探讨中药抗骨痛注射液治疗局部软组织增生、水肿、刺痛或压迫神经的作用机制。设计:随机对照研究。单位:解放军第二○二医院理疗科,上海中医药大学实验动物部。材料:实验于2002-05/2003-01在上海中医药大学实验动物部完成,并由该部提供4月龄健康雌性SD大鼠21只,清洁级,按体质量随机抽样分成3组,即对照组、地塞米松组、抗骨痛组,每组7只大鼠。方法:对照组,腹腔注射生理盐水6mL;地塞米松组,腹腔注射0.08g/L地塞米松6mL;抗骨痛组,腹腔注射抗骨痛注射液6mL,0.5h后,在3组大鼠右踝关节周围每只注入0.3mL的尿酸钠(25g/L)造成关节炎,分别在实验前和实验后10,20h检测右踝关节的周径。主要观察指标:实验前和实验后10,20h大鼠右踝关节的周径。结果:3组大鼠右踝关节在尿酸钠的作用下发生了无菌性关节炎,局部肿胀。由于各组在腹腔内注射了不同药物,而使关节肿胀不同。实验后10h关节肿胀程度比较:对照组、地塞米松组及抗骨痛组的关节周径分别为(57.80±2.26),(31.12±5.11)及(43.86
BACKGROUND: The use of anti-bone pain injection to treat joint swelling and pain after multiple screening of traditional Chinese medicine and clinical observation for more than 10 years, the effect of eliminating joint swelling, cervical spondylosis, osteoarthritis symptoms and signs is more prominent. In order to further study the mechanism of anti-bone pain on the treatment of joint swelling, cervical spondylosis, osteoarthritis, the author made animal experiments. OBJECTIVE: To explore the mechanism of traditional Chinese medicine anti-gutong injection in the treatment of local soft tissue hyperplasia, edema, tingling, or oppression of nerves. Design: Randomized controlled study. Unit: Department of Physiotherapeutics, No.102 Hospital of PLA, Laboratory Animal Department, Shanghai University of Traditional Chinese Medicine. MATERIALS: The experiment was performed at the Laboratory Animal Department of Shanghai University of Traditional Chinese Medicine from May 2002 to January 2003. The department provided 21 healthy female SD rats of 4 months of age, clean grade, and were divided into 3 groups according to the random sampling of body mass. Control group, dexamethasone group, anti-bone pain group, 7 rats in each group. Methods: In the control group, 6 mL normal saline was injected intraperitoneally; In the dexamethasone group, 6 mL of 0.08 g/L dexamethasone was injected intraperitoneally; In the anti-bone pain group, 6 mL of anti-osteoinjection was injected intraperitoneally, 0.5 h later, in 3 groups of rats Injecting 0.3 mL of sodium urate (25 g/L) into the right ankle joint resulted in arthritis. The circumference of the right ankle joint was measured before and 10 and 20 hours after the experiment. MAIN OUTCOME MEASURES: Weekly diameters of right ankle joints of rats at 10 and 20 hours before and after the experiment. RESULTS: The right ankle joints of three groups of rats developed aseptic arthritis and localized swelling under the action of sodium urate. As each group was injected with different drugs in the abdominal cavity, swelling of the joints was different. The degree of joint swelling at 10 h after the experiment: the diameters of the joints in the control group, dexamethasone group and anti-bone pain group were (57.80±2.26), (31.12±5.11) and (43.86, respectively).