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目的观察复方嗜酸乳杆菌片联合奥美拉唑肠溶片治疗急性肠胃炎患者的效果。方法选取2015年1月—2016年1月在本院接受治疗的急性肠胃炎患者98例作为调查对象。采用随机分组的原则将患者分为对照组与观察组各49例。对照组患者给予复方嗜酸乳杆菌进行治疗,观察组则在对照组用药的基础上联合给予奥美拉唑肠溶片进行治疗,观察两组患者的治疗效果及用药安全性。计数资料比较采用χ~2检验,计量资料比较采用t检验,P<0.05为差异有统计学意义。结果观察组的治疗总有效率(89.8%)明显比对照组(59.2%)高,差异有统计学意义(P<0.05)。观察组治疗后不良反应发生率(20.4%)明显少于对照组(40.8%),差异有统计学意义(P<0.05)。治疗后观察组消化系统症状评分显著低于对照组[(3.2±1.8)、(6.8±2.2)分],胃肠功能评分显著高于对照组[(2.7±0.9)、(4.3±1.1)分],差异均有统计学意义(均P<0.05)。干预后观察组营养风险评分显著低于对照组[(3.14±0.36)、(4.82±0.65)分],差异有统计学意义(P<0.05)。结论单一使用复方嗜酸乳杆菌治疗急性肠胃炎患者效果并不理想,联合奥美拉唑肠溶片能够显著改善患者的临床症状,安全性较高,值得推广应用。
Objective To observe the effect of compound acidophilus Lactobacillus tablets combined with omeprazole enteric-coated tablets in patients with acute gastroenteritis. Methods A total of 98 patients with acute gastroenteritis treated in our hospital from January 2015 to January 2016 were selected as the survey subjects. Patients were divided into control group and observation group by using the principle of random grouping. Patients in the control group were given compound Lactobacillus acidophilus for treatment. The observation group was treated with omeprazole enteric-coated tablets on the basis of the control group, and the therapeutic effect and medication safety were observed in both groups. Counting data were compared using χ ~ 2 test, measurement data were compared using t test, P <0.05 for the difference was statistically significant. Results The total effective rate of observation group (89.8%) was significantly higher than that of control group (59.2%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group (20.4%) was significantly less than that in the control group (40.8%), the difference was statistically significant (P <0.05). The score of digestive system symptom in observation group was significantly lower than that in control group [(3.2 ± 1.8), (6.8 ± 2.2) points], and the gastrointestinal function score was significantly higher than that in control group [(2.7 ± 0.9), (4.3 ± 1.1) points ], The differences were statistically significant (all P <0.05). After intervention, the nutrition risk score of the observation group was significantly lower than that of the control group [(3.14 ± 0.36), (4.82 ± 0.65) points], the difference was statistically significant (P <0.05). Conclusion The single use of Lactobacillus acidophilus in the treatment of patients with acute gastroenteritis is not effective. The combination of omeprazole enteric-coated tablets can significantly improve the clinical symptoms of patients with high safety and is worth popularizing and applying.