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目的:观察“717复方”制剂对内毒素休克大鼠肝细胞线粒体的保护作用。方法:采用静脉注射内毒素制备大鼠内毒素休克模型,观察“717复方”对休克大鼠肝细胞线粒体功能的影响。结果:模型组大鼠肝细胞线粒体呼吸控制率(RCR)明显下降,与正常对照组比较(4.58±0.31比5.73±0.35)有显著性差异(P<0.05);电镜下,内毒素休克模型线粒体明显肿胀,嵴减少、模糊不清。“717复方”制剂组大鼠肝细胞线粒体RCR(5.68±0.41)则接近正常,与模型组比较有极显著性差异(P<0.01);其电镜下超微结构病变也较轻。体外实验测定肝细胞线粒体膜通透性(膜吸光度下降百分比),“717复方”制剂组明显低于内毒素组(P<0.01)。结论:“717复方”制剂具有拮抗内毒素损伤线粒体的作用
OBJECTIVE: To observe the protective effect of “717 compound prescription” on mitochondria of hepatocytes in endotoxic shock rats. METHODS: Rat endotoxin shock model was prepared by intravenous injection of endotoxin. The effect of “717 compound prescription” on hepatocyte mitochondrial function in shock rats was observed. RESULTS: The mitochondrial respiratory control rate (RCR) of hepatocytes in the model group was significantly decreased compared with the normal control group (4.58±0.31 vs. 5.73±0.35) (P<0.05). Under the electron microscope, the mitochondria in the endotoxin shock model was significantly swollen, and the hernia was reduced and unclear. The RCR (5.68±0.41) of hepatocyte mitochondria in rats of “717 Fufang” preparation group was close to normal, and there was a significant difference compared with the model group (P<0.01). Ultrastructural lesions were also observed under electron microscope. Lighter. The mitochondrial membrane permeability of liver cells was measured in vitro (percent decrease in membrane absorbance), and the “717 compound prescription” group was significantly lower than the endotoxin group (P <0.01). Conclusion: The “717 Compound Formulation” has the effect of antagonizing endotoxin damage mitochondria