论文部分内容阅读
目的探讨呼出气一氧化氮(Fe NO)检测在慢性喘息型支气管炎(以下简称慢喘支)和支气管哮喘(以下简称哮喘)两种疾病急性发作时的水平及意义。方法随机选取就诊于该院呼吸内科门诊的慢喘支急性发作患者52例(慢喘支组)和哮喘急性发作患者48例(哮喘组),采用一氧化氮检测仪检测所有患者的Fe NO水平,同时检测外周血嗜酸性粒细胞比率(EOS%)及肺功能等指标并进行分析。结果慢喘支组Fe NO水平和EOS%低于哮喘组,差异有统计学意义(P<0.01);慢喘支组各项肺功能指标优于哮喘组,差异有统计学意义(P<0.01);慢喘支组Fe NO水平与肺功能各项指标、EOS%无关(P>0.05);哮喘组Fe NO水平与肺功能各项指标无关(P>0.05),但与EOS%呈正相关(r=0.626,P<0.01)。结论 Fe NO、EOS%及肺功能等指标可为慢喘支和哮喘两种疾病急性发作时的鉴别提供一定参考。
Objective To investigate the significance and significance of the detection of exhaled nitric oxide (Fe NO) in acute episodes of chronic asthmatic bronchitis (chronic asthma bronchitis) and bronchial asthma (asthma). Methods Fifty-two patients with COPD (COPD group) and 48 patients with acute asthma exacerbation (asthma group) were selected randomly from the outpatient department of respiratory medicine in the hospital. The level of Fe (NO) in all patients was detected by nitric oxide detector At the same time, the indexes of peripheral blood eosinophil (EOS%) and pulmonary function were detected and analyzed. Results The levels of Fe (superscript +) and EOS% in chronic bronchitis group were lower than those in asthma group (P <0.01). The pulmonary function indexes in chronic bronchitis group were better than those in asthma group (P <0.01) ). The level of Fe (superscript +) in chronic bronchitis group was not related to the indexes of pulmonary function and EOS% (P> 0.05). The levels of Fe and NO in asthma group were not related with the indexes of pulmonary function (P> 0.05) r = 0.626, P <0.01). Conclusion The indexes such as Fe NO, EOS% and pulmonary function may provide some reference for the differential diagnosis of chronic asthma and chronic asthma.