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目的探讨耐多药肺结核治疗中不良反应的发生情况。方法选取2013年2月至2014年2月收治的耐多药肺结核患者45例作为研究对象,对耐多药肺结核治疗中出现的不良反应情况进行分析。结果 45例耐多药肺结核患者中,有4例患者未发生不良反应,41例患者发生不良反应,其中肝功能异常8例,肠胃道反应14例,低血钾7例,尿蛋白异常4例,尿酸升高、药物疹各3例,视听下降、血清促甲状腺激素异常各1例。结论耐多药肺结核治疗中不良反应最为严重的是肠胃道反应,及时发现并制订有效的治疗方案可提高治疗效果。
Objective To investigate the incidence of adverse reactions in multi-drug resistant pulmonary tuberculosis. Methods Forty-five MDR-TB patients admitted from February 2013 to February 2014 were selected as the research object to analyze the adverse reactions occurred in MDR-TB treatment. Results Of the 45 MDR-TB patients, 4 patients had no adverse reactions and 41 patients had adverse reactions. Among them, 8 were liver dysfunction, 14 were gastrointestinal reactions, 7 were hypokalemia, 4 were urinary protein abnormalities , Uric acid, drug rash in 3 cases, audio-visual decline, serum thyrotropin abnormalities in 1 case. Conclusions The most serious adverse reactions in MDR-TB treatment are gastrointestinal reactions, and timely detection and formulation of effective treatment regimens can improve the therapeutic effect.