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本文报告1988年1月至1990年12月,用高剂量顺铂(120mg/M~2)为主的术前诱导化疗治疗口腔颌面部鳞癌的近期疗效和毒性反应,其CR+PR为9O.6％。38例初治者CR+PR为94.7％,5例复治者为60.0％。化疗的毒副反应有骨髓抑制、消化道反应、脱发,而肾、肝、心和神经系统毒副反应较轻。术前诱导化疗应一疗程为宜。
This article reports the short-term efficacy and toxicity of preoperative induction chemotherapy with high-dose cisplatin (120 mg/M~2) from January 1988 to December 1990 in patients with oral and maxillofacial squamous cell carcinoma. The CR+PR is 9O.6%. CR+PR was 94.7% in 38 untreated cases and 60.0% in 5 cases treated. The toxicities and side effects of chemotherapy include bone marrow suppression, digestive tract reactions, and hair loss. The renal, hepatic, cardiac, and nervous system toxicities are relatively mild. Preoperative induction chemotherapy should be a course of treatment is appropriate.