论文部分内容阅读
本文用胃癌细胞系(GGC—8140)免疫BALB/C小鼠,获得了一系列抗胃癌细胞的McAbs。经IFS和ABC测定其反应性,可将其分为三种类型:(1)只与靶细胞反应,不与其它细胞或组织反应。(2)不但与靶细胞反应,还与正常及癌瘤组织反应。(3)与靶细胞、裸大鼠胃癌模型、某些癌及非癌组织反应,但是,与绝大多数正常组织细胞以及CEA、AFP、β_2M、HCG无反应,反应特点是与起源于腺上皮细胞的癌组织反应明显除后者外其它二类均不是肿瘤特异性抗体。
In this study, BALB/C mice were immunized with a gastric cancer cell line (GGC-8140) and a series of anti-gastric cancer McAbs were obtained. The reactivity of IFS and ABC can be divided into three types: (1) only react with target cells and not react with other cells or tissues. (2) Not only react with target cells, but also react with normal and cancerous tissues. (3) Reacts with target cells, nude rat gastric cancer models, certain cancerous and non-cancerous tissues, but does not respond to most normal tissue cells and CEA, AFP, β_2M, and HCG. The response is characteristic of originating in glandular epithelium. In addition to the latter, the other two types of cells are not tumor-specific antibodies.