近几年来,庆大霉素(Gentamycin,GM)的应用越来越普遍滥用和不合理应用的现象屡见发生。根据统计,1980—1981年,上海市抗生素处方中GM占19％,81年医院中GM用量及使用人次较80年增加30.9％,82年后仍在上升。随之而来的是细菌对GM耐药率的逐步上升,疗效的下降和其不良反应给人们带来的危害有所增加。如上海地区1980—82年对绿脓杆菌的耐药率为42—49％,四川地区1980年测定绿脓杆菌对GM的耐药率已上升至65.6％,而国外某医院1981—1982 In recent years, the application of gentamycin (Gentamycin, GM) is more and more common abuse and irrational application of the phenomenon often occur. According to statistics, in 1980-1981, GM accounted for 19% of antibiotics prescriptions in Shanghai. The amount of GM used in hospitals in 81 years and the number of users increased by 30.9% over those of 80 years and still increased after 82 years. Followed by the gradual increase in bacterial resistance to GM, the decline in efficacy and the adverse effects caused by their adverse reactions have increased. For example, the rate of resistance to Pseudomonas aeruginosa in Shanghai in 1980-82 was 42-49%. In Sichuan, the resistance rate of Pseudomonas aeruginosa to GM was increased to 65.6% in 1980, while that of a foreign hospital in 1981-1982