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无选择的100例胃癌切除标本中,78例癌旁粘膜内含有不同程度的肠上皮化生(肠化),22例无肠化。在伴肠化的78例癌中,高分化癌占27例,(34.6％),低分化—末分化癌占51例(65.4％)。通过几种组织化学技术把肠化分为小肠型、硫酸粘蛋白结肠型(硫结肠型)和氧乙酰唾酸—硫酸粘蛋白结肠型(氧硫结肠型)及氧乙酰唾酸粘蛋白结肠型(氧结肠型)。氧硫结肠型肠化在高分化癌中的发生率(22/27)要明显高于低分化—末分化癌中的发生率(17/51)(X~2=14.5011,P<0.001)。这就提示,氧硫结肠型化生中的氧乙酰唾酸粘蛋白可能与胃癌发生时分化的高低有关。即是说、含有氧乙酰唾酸粘蛋白的氧硫结肠型在恶性转化中多倾向于发展为高分化癌。
In the unselected 100 cases of gastric cancer resection specimens, 78 cases of paraneoplastic mucosa contained varying degrees of intestinal metaplasia (intestinal metaplasia) and 22 cases had no intestinal metaplasia. Among the 78 cases with intestinal metastases, 27 cases were highly differentiated (34.6%), and 51 cases (65.4%) were poorly differentiated and terminally differentiated. Intestinal metaplasia is classified into small intestine type, mucinous sulphate colon type (sulfur colon type), and oxyacetylsalicylic acid-sulfatocadherin colon type (oxysulfuric colon type) and oxyacetyl sialic acid mucin colon type by several histochemical techniques (Oxycolic type). The incidence of oxygen-sulfuric colonic metastasis in well-differentiated carcinomas (22/27) was significantly higher than that in poorly-differentiated-over-differentiated carcinomas (17/51) (X~2=14.5011, P<0.001). This suggests that the oxygen acetylsulphate mucin in the colon of oxygen-sulfur may be related to the differentiation of gastric cancer. That is, the oxygen-sulfur colon type containing oxyacetyl sialylated mucin tends to develop into a well-differentiated carcinoma in malignant transformation.