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目的探讨2型糖尿病患者大血管病变与血脂的关系。方法将215例2型糖尿病患者分成两组,伴发大血管病变组83例,不伴大血管病变组132例,分别测定各组的TC、TG、LDL-C、HDL-C水平并作比较。结果2型糖尿病伴发大血管病变组中TC、TG、LDL-C、HDL-C较不伴大血管病变组明显升高(P<0.05或P<0.01),而HDL-C较不伴大血管病变组明显下降(P<0.05),血脂情况与大血管病变关系的Logistic回归分析显示:TG、LDL-C、HDL-C为2型糖尿病伴发大血管病变的独立危险因素,偏回归系数B分别为-1.232、-2.216、2.452。结论2型糖尿病伴发大血管病变患者血脂水平明显异常,其中TG、LDL-C、HDL-C为2型糖尿病患者伴发大血管病变的独立危险因素,且小而致密的LDL-C为主要危险因素,TC与2型糖尿病患者的大血管病变有关,但不是独立危险因素。
Objective To investigate the relationship between macrovascular disease and serum lipids in type 2 diabetic patients. Methods 215 patients with type 2 diabetes were divided into two groups: 83 cases with macrovascular disease group and 132 cases without macrovascular disease group. The levels of TC, TG, LDL-C and HDL-C in each group were measured and compared . Results The levels of TC, TG, LDL-C and HDL-C in patients with type 2 diabetes mellitus and those with macrovascular complications were significantly higher than those without macrovascular complications (P <0.05 or P <0.01), while those with HDL-C (P <0.05). Logistic regression analysis of the relationship between lipid status and macrovascular disease showed that TG, LDL-C and HDL-C were independent risk factors for type 2 diabetes with macrovascular disease, partial regression coefficient B are -1.232, -2.216, 2.452 respectively. Conclusion The levels of serum lipids in patients with type 2 diabetes mellitus and those with macrovascular disease are significantly abnormal. Among them, TG, LDL-C and HDL-C are independent risk factors for macrovascular complications in patients with type 2 diabetes mellitus, with small and dense LDL-C as the main Risk factors, TC and type 2 diabetic patients with macrovascular disease, but not an independent risk factor.