丙基硫氧嘧啶(PTU)是治疗Graves病最常用的药物,近年来不断有报道提示在用PTU治疗的病人中出现 抗中性粒细胞胞浆抗体(ANCA),并可导致自身免疫性血管炎。临床多表现为全身系统受累,肾脏是最易受累的器 官,肾外最常见的是肺脏、皮肤、粘膜,还可表现为狼疮样综合征。本病的预后与病程有关,及时停药是关键。 Propylthiouracil (PTU) is the most commonly used drug in the treatment of Graves’ disease. It has been repeatedly reported in recent years that anti-neutrophil cytoplasmic antibodies (ANCA) appear in patients treated with PTU and can lead to autoimmune blood vessels inflammation. More clinical manifestations of systemic involvement, the kidney is the most vulnerable organs, the most common outside the lungs are the lungs, skin, mucous membranes, but also the performance of lupus-like syndrome. The prognosis of the disease and duration of the disease, the timely withdrawal is the key.