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目的 观察厄贝沙坦对高血压患者左室肥厚 (LVH)的逆转作用及对QT离散度 (QTd)和校正QTd(QTcd)的影响。方法 6 8例高血压患者分为LHV组 38例和非LHV组 30例 ,口服厄贝沙坦 15 0mg/d治疗后 6个月观察治疗前后左室重量指数 (LVMI)、QTd和QTcd的改变。结果 两组患者用药后收缩压(SBP)和舒张压 (DBP)显著降低 (P <0 0 1) ,LHV组治疗后较治疗前室性心律失常 (VA)明显改善 ,LVMI显著降低、QTd和QTcd显著缩短 (P <0 0 1)。结论 厄贝沙坦具有良好的降压效果 ,还可逆转心肌肥厚 ,降低QTd和QTcd ,减少恶性心律失常的发生 ,从而改善高血压LVH患者的预后
Objective To observe the reversal effect of irbesartan on left ventricular hypertrophy (LVH) and its effect on QTd and QTd (QTd) in hypertensive patients. Methods Sixty-eight patients with hypertension were divided into three groups: 38 in the LHV group and 30 in the non-LHV group. Changes in left ventricular mass index (LVMI), QTd and QTcd were observed before and after treatment with irbesartan at 15 mg / d . Results The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the two groups were significantly decreased after treatment (P <0.01), and the LVV was significantly lower than that before treatment in LVH group QTcd was significantly shorter (P <0.01). Conclusion Irbesartan has a good antihypertensive effect, but also can reverse cardiac hypertrophy, reduce QTd and QTcd, reduce the incidence of malignant arrhythmia, thereby improving the prognosis of hypertensive patients with LVH