1例69岁男性患者因酒精性肝硬化合并上消化道出血给予垂体后叶素24 U加入0.9%氯化钠注射液50 ml持续静脉泵入、1次/12 h，同时常规给予奥美拉唑、奥曲肽、血凝酶、血浆及对症支持治疗。第2天患者出现舌体肿大，考虑可能与药物治疗有关，给予地塞米松5 mg静脉注射，异丙嗪25 mg肌内注射。4 h后患者舌体恢复正常。由于出血症状好转，停用垂体后叶素，其他药物继续使用。8 d后，患者再次出现黑便，再次给予垂体后叶素治疗。次日，患者再次出现舌体肿大，经同样处理后好转。考虑患者舌体肿大为垂体后叶素引起的血管性水肿。“,”A 69-year-old male patient was given pituitrin 24 U dissolved in 0.9% sodium injection for continuous intravenous pump once per 12 hours for alcoholic cirrhosis complicated by upper gastrointestinal hemorrhage. At the same time, omeprazole, octreotide, hemocoagulase, plasma, and symptomatic and supportive treatments were given conventionally. On the second day, the patient developed tongue swelling. Considering that it might be related to therapeutic drugs, intravenous injection of dexamethasone 5 mg and intramuscular injection of promethazine 25 mg were given. Due to the improvement of bleeding symptoms, pituitrin was stopped and other drugs continued to be used. Eight days later, black stool recurred in the patient and pituitrin was given again. The next day, the patient had tongue swelling again, which was improved after the same treatments. The patient′s tongue swelling was considered as angioedema caused by pituitrin.