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目的 :观察愈肝片对大鼠四氯化碳慢性肝损伤的保护作用。方法 :以 0 2ml/kg体重剂量经大鼠腹腔注射 30 %四氯化碳色拉油溶液制作慢性肝损伤模型 ,观察给药前后大鼠血清AST、ALT ,TP和ALB的变化。结果 :愈肝片高、中剂量组及阳性药肝脾康对照组均可明显降低肝损伤大鼠血清AST、ALT水平 ;高剂量组可明显升高肝损伤大鼠血清总蛋白和白蛋白含量。结论 :愈肝片对四氯化碳慢性肝损伤有明显保护作用 ,对其血清蛋白的改变有一定调节作用。
Objective: To observe the protective effect of Yugan Tablet on carbon tetrachloride chronic liver injury in rats. METHODS: A rat model of chronic liver injury was made by intraperitoneal injection of 30 % carbon tetrachloride salad oil at a dose of 0 2 ml/kg body weight. Changes in serum AST, ALT, TP and ALB were observed before and after administration. RESULTS: The high-dose group and the middle-dose group and the positive control liver and spleen-kang control group can significantly reduce the serum AST and ALT levels in the liver injury rats; the high-dose group can significantly increase the serum total protein and albumin levels in the liver injury rats. . Conclusion : Yugan Pian has a protective effect on chronic liver injury induced by carbon tetrachloride, and it can regulate the change of serum protein.