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The prevalence of obesity and its associated diseases hasposed a huge healthcare impact on our society.Obesity is amajor risk factor for many serious medical conditions,suchas metabolic syndrome,Type 2 Diabetes and cardiovasculardisorders etc.In addition,the close association of obesitywith cancers has attracted significant attentions[1].Severalobesity-related cancers,including breast,prostate,endo-metrium,colon and gallbladder cancer,have a hormonalbasis and are life style-related.Breast cancer is the mostfrequent cancer and the second leading cause of cancerdeath among women.Excess adiposity over the pre-andpost-menopausal years is an independent risk factor for thedevelopment of breast cancer,and is also associated withlate-stage disease and poor prognosis[2].Adipose tissue has been shown to be an important playerin obesity-related mammary carcinogenesis[2].Adipocyteis one of the predominant stromal cell types in the microen-vironment of mammary tissue.It is also the major site forlocal estrogen production from androgens by aromatase,
The prevalence of obesity and its associated diseases hasposed a huge healthcare impact on our society .Obesity is amajor risk factor for many serious medical conditions, suchas metabolic syndrome, Type 2 Diabetes and cardiovascular disorders etc.In addition, the close association of obesitywith cancers significant attentions [1] .Severalobesity-related cancers, including breast, prostate, endo-metrium, colon and gallbladder cancer, have a hormonalbasis and are life style-related.Breast cancer is the mostfrequent cancer and the second leading cause of cancerdeath among women .Excess adiposity over the pre-andpost-menopausal years is an independent risk factor for the development of breast cancer, and is also associated with plate-stage disease and poor prognosis [2]. Adipose tissue has been shown to be important playerin obesity-related mammary carcinogenesis [2] .Adipocyteis one of the predominant stromal cell types in the microen-vironment of mammary tissue. It is also the major site forl ocal estrogen production from androgens by aromatase,