论文部分内容阅读
目前临床上血清胆碱酯酶(ChE)主要用来诊断有机磷农药中毒和评估肝脏功能状况。但近年来国内外一些研究发现,血清ChE活性可能与全身炎性反应综合征(SIRS)有关。SIRS患者血清ChE活性降低,其降低程度可能和预后相关。血清ChE活性降低的原因可能与肝功能损害、分解代谢增强、稀释和血管外漏及机体通过“胆碱能抗炎通路”下调胆碱酯酶活性有关。应用ChE抑制剂可对抗SIRS时的过度炎性反应。
The clinical serum cholinesterase (ChE) is mainly used to diagnose organophosphorus pesticide poisoning and assess the status of liver function. However, in recent years, some studies at home and abroad have found that serum ChE activity may be related to systemic inflammatory response syndrome (SIRS). Serum ChE activity is reduced in patients with SIRS, the extent of which may be related to the prognosis. Serum ChE activity may be due to decreased liver function, increased catabolism, dilution and vascular leakage and the body through the “cholinergic anti-inflammatory pathway” down the cholinesterase activity. ChE inhibitors can be used against SIRS excessive inflammatory reaction.