[目的]研究慢性肾脏病(CKD)患者血浆脑钠素(BNP)水平与肾功能水平及中医辨证分型的关系。[方法]回顾性研究我院2008年3月1日至2008年12月31日期间52例单纯慢性肾脏病患者资料,根据K/DOQI指南和中医辨证分型进行分组,并测定血浆BNP水平。采用SPSS11.0统计软件进行统计学分析。[结果]单纯慢性肾功能衰竭患者的血浆BNP水平均较正常组为高,且随eGFR的减少而逐渐增高,各组与健康对照组差异有统计学意义(P<0.01)。CKD各组之间差异有统计学意义(P<0.05)。BNP水平在中医各证型中的趋势为脾肾气虚<气阴两虚<脾肾阳虚<阴阳两虚。[结论]血浆BNP浓度随中医证型和慢性肾脏病分期的加重而升高。慢性肾脏病肾功能水平可影响血浆BNP水平。慢性肾脏病中医辨证分型与血浆BNP水平存在相关性。 [Objective] To investigate the relationship between plasma brain natriuretic peptide (BNP) levels and renal function and TCM syndrome differentiation in patients with chronic kidney disease (CKD). [Methods] The data of 52 patients with chronic kidney disease in our hospital from March 1, 2008 to December 31, 2008 were retrospectively studied. The patients were divided into group according to K / DOQI guidelines and TCM syndrome differentiation and plasma BNP levels were measured. Using SPSS11.0 statistical software for statistical analysis. [Results] Plasma BNP levels in patients with chronic renal failure were significantly higher than those in normal controls and gradually increased with the decrease of eGFR. There was significant difference between each group and healthy controls (P <0.01). The difference between CKD groups was statistically significant (P <0.05). BNP levels in TCM syndromes in the trend for the spleen and kidney qi and yin Deficiency