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目的比较不同剂量米非司酮治疗子宫肌瘤的临床疗效。方法选取2015年1月—2016年1月浚县人民医院收治的子宫肌瘤患者101例,按照随机数字表法将患者分为对照组50例与试验组51例。对照组患者给予12.5mg米非司酮治疗,试验组患者给予25mg米非司酮治疗,比较两组患者临床疗效、子宫肌瘤体积、激素水平[促卵泡素(FSH)、促黄体生成素(LH)、雌二醇(E_2)、孕酮(P)]、不良反应发生情况。结果试验组患者总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前后两组患者子宫肌瘤体积比较,差异无统计学意义(P>0.05);治疗后两组患者子宫肌瘤体积小于治疗前,差异有统计学意义(P<0.05)。治疗前两组患者FSH、LH、E_2、P水平比较,差异无统计学意义(P>0.05);治疗后试验组患者FSH、LH、E_2、P水平低于对照组,差异有统计学意义(P<0.05)。试验组患者不良反应发生率高于对照组,差异有统计学意义(P<0.05)。结论大剂量米非司酮治疗子宫肌瘤的临床疗效优于小剂量,但大剂量米非司酮不良反应大,不可长时间服用。
Objective To compare the clinical efficacy of different doses of mifepristone in the treatment of uterine fibroids. Methods From January 2015 to January 2016, 101 cases of uterine fibroids were treated in Junxian People’s Hospital. According to the random number table, the patients were divided into control group (n = 50) and experimental group (n = 51). The patients in the control group were given 12.5 mg mifepristone and the patients in the test group were given 25 mg mifepristone. The clinical efficacy, the volume of uterine fibroids, the levels of hormones [follicle stimulating hormone (FSH), luteinizing hormone (LH) , Estradiol (E2), progesterone (P)], the occurrence of adverse reactions. Results The total effective rate of the experimental group was higher than that of the control group, the difference was statistically significant (P <0.05). The volume of uterine fibroids in the two groups before and after treatment showed no significant difference (P> 0.05). After treatment, the volume of uterine fibroids in both groups was smaller than before treatment (P <0.05). The levels of FSH, LH, E_2, P in the two groups before treatment were not significantly different (P> 0.05). After treatment, the levels of FSH, LH, E_2, P in the experimental group were lower than those in the control group P <0.05). The incidence of adverse reactions in the experimental group was higher than that in the control group, with significant difference (P <0.05). Conclusion The high dose of mifepristone is superior to low dose in the treatment of uterine fibroids, but the large dose of mifepristone has a large adverse reaction and can not be taken for a long time.