皮质醇增多症可分为非促肾上腺皮质激素(ACTH)依赖性和ACTH依赖性两类,前者是原发于肾上腺皮质的肿瘤(柯兴综合征),后者包括分泌ACTH的垂体腺瘤(柯兴病)和分泌ACTH和(或)促肾上腺皮质激素释放因子(CRF)的垂体外肿瘤(异位ACTH综合征),包括肺癌、胸腺癌、胰腺癌、神经嵴细胞瘤(嗜铬细胞瘤、神经母细胞瘤、副神经节瘤和神经节瘤)和甲状腺髓样癌等。这些肿瘤合成和 Cortisol hyperplasia can be divided into non-adrenocorticotropic hormone (ACTH)-dependent and ACTH-dependent tumors. The former is a primary tumor in the adrenal cortex (Cushing’s syndrome), and the latter includes pituitary adenomas that secrete ACTH ( Cushing’s disease) and pituitary tumors that secrete ACTH and/or corticotropin releasing factor (CRF) (ectopic ACTH syndrome), including lung cancer, thymic cancer, pancreatic cancer, neuroblastoma (pheochromocytoma , neuroblastoma, paraganglioma, and ganglionoma) and medullary thyroid carcinoma. These tumors synthesize and