Surface contact explosion experiments have been performed for the study of dynamic response of the hard-soft-hard sandwich panel under blast loading. Experimental results have shown that there are four damage modes, including explosion cratering, scabbing of the backside, radial cracking induced failure and circumferential cracking induced failure. It also illustrates that the foam material sandwiched in the multi-layered media has an important effect on damage patterns. The phenomena encountered have been analyzed by the calculation with ALE method. Meanwhile, the optimal analysis of foam material thickness and position in the sandwich panel were performed in terms of experimental and numerical analysis. The proper thickness proportion of the soft layer is about 20% to the thickness of sandwich panel and the thickness of the upper hard layer and lower hard layer is in the ratio of 7 to 3 under the condition in this paper when the total thickness of soft layer remains constant. Surface contact explosion experiments have been performed for the study of dynamic response of the hard-soft-hard sandwich panel under blast loading. Experimental results have shown that there are four damage modes, including explosion cratering, scabbing of the backside, radial cracking induced failure and circumferential cracking induced failure. It also illustrates that the foam material sandwiched in the multi-layered media has an important effect on damage patterns. and position in the sandwich panel were performed in terms of experimental and numerical analysis. The proper thickness proportion of the soft layer is about 20% to the thickness of sandwich panel and the thickness of the upper hard layer and lower hard layer is in the ratio of 7 to 3 under the condition in this paper when the total thickness of soft layer remains constant.