论文部分内容阅读
目的探讨益气活血复方对局灶性脑缺血模型大鼠神经功能、脑梗死体积、脑组织中IL-6mRNA表达水平的作用。方法用电凝法造模,应用神经功能行为学评分、免疫组织化学和分子生物学技术。结果与模型组比较,益气活血复方各组的神经功能评分减少,脑梗死体积缩小,IL-6mRNA表达不同程度下调,具有量效关系。结论减少炎性细胞因子引起的炎症反应可能是益气活血复方治疗急性脑梗死,改善神经功能缺失和缩小脑梗死体积的作用机制之一。
Objective To investigate the effects of Yiqi Huoxue Compound on neurological function, volume of cerebral infarction and IL-6 mRNA expression in brain tissue in focal cerebral ischemia model rats. Methods The method of electrocoagulation was used to establish neurological functional behavioral score, immunohistochemistry and molecular biology techniques. Results Compared with the model group, the scores of neurological function of Yiqi Huoxue Compound group decreased, the volume of cerebral infarction was reduced, and the expression of IL-6 mRNA was down-regulated to some extent, with dose-effect relationship. Conclusions Reducing the inflammatory response induced by inflammatory cytokines may be one of the mechanisms of Yiqihuoxue compound in treating acute cerebral infarction, improving neurological deficit and reducing the volume of cerebral infarction.