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应用Ｓ－Ｐ免疫组化方法，研究ｐ~（５３）在８８例原发性胃癌患者的表达变化与肿瘤细胞增殖和浸润深度及淋巴结转移的关系。发现ｐ~（５３）阳性染色率为４８．９％，ｐ~（５３）阳性染色与肿瘤浸润深度及癌细胞增殖活性呈正相关，ｐ~（５３）阳性肿瘤的淋巴结转移率（９３％）明显高于ｐ~（５３）阴性的肿瘤（６０％，Ｐ＜０．０５）。提示ｐ~（５３）过表达在胃癌淋巴结转移和肿瘤浸润及增殖中起重要作用。
S-P immunohistochemistry was used to study the relationship between the expression of p53 in 88 cases of primary gastric cancer and the relationship between tumor cell proliferation, infiltration depth and lymph node metastasis. The positive rate of p53 staining was 48.9%. The p53 positive staining was positively correlated with the depth of tumor invasion and the proliferation activity of cancer cells. The lymph node metastasis rate of p53 positive tumors was significantly higher (93%). Higher than p53 negative tumors (60%, P < 0.05). It suggests that p53 overexpression plays an important role in lymph node metastasis and tumor invasion and proliferation of gastric cancer.