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目的探讨双胎合并妊娠期肝内胆汁淤积症(ICP)的发病机制、围生儿预后和治疗。方法回顾性分析2008年4月至2011年12月我院收治的13例双胎合并ICP患者的临床资料。结果 13例ICP患者均有不同程度的皮肤瘙痒症状,其中1例于孕35+3周早产顺产外,余12例均在积极干预后剖宫产终止妊娠。结论一旦确诊为双胎合并ICP,都必须积极保肝降胆酸治疗,密切监测母婴情况,适时以适当方式终止妊娠,尽量确保母婴安全。
Objective To investigate the pathogenesis of perinatal complicating pregnancy with intrahepatic cholestasis (ICP), prognosis and treatment of perinatal infants. Methods The clinical data of 13 consecutive twins with ICP in our hospital from April 2008 to December 2011 were retrospectively analyzed. Results All the 13 patients had different degrees of pruritus. Among them, 1 patient was prematurely delivered at 35 + 3 weeks of gestation, and the remaining 12 patients were terminated by cesarean section after positive intervention. Conclusions Once the diagnosis of twin pregnancy with ICP, we must actively protect liver and bile acid treatment, close monitoring of maternal and infant conditions, timely and appropriate termination of pregnancy, try to ensure the safety of mother and child.