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目的：观察心肌受照射面积及照射剂量对血清心肌酶学改变的影响。方法：对８６例射野累及心脏的肺癌和食管癌病人行６０Ｃｏ线照射，并在照射前、照射中和照射结束时检测血清ＬＤＨ、ＡＳＴ、ＣＫ及ＣＫ－ＭＢ浓度的改变，同时行心电图检查。结果：①血清ＬＤＨ及ＡＳＴ浓度无显著改变。②血清ＣＫ浓度在心脏受照射面积占心脏面积５０％以上，且照射剂量高于６０Ｇｙ时出现升高。③血清ＣＫ－ＭＢ浓度在心脏受照射面积占心脏面积５０％以上时出现升高。④有２例患者心电图出现ＳＴ段改变，占全部病例的２．３％。结论：血清ＣＫ浓度的改变与心脏受照射面积及照射剂量相关，血清ＣＫ－ＭＢ浓度的改变仅与心脏受照射面积相关。
Objective: To observe the influence of myocardial irradiation area and irradiation dose on serum myocardial enzymology. Methods: Sixty-six patients with lung cancer and esophageal cancer involving in the field were irradiated with 60Co ray and the serum concentrations of LDH, AST, CK and CK-MB were measured before irradiation, at the end of irradiation and at the end of irradiation. At the same time, electrocardiogram an examination. Results: ① Serum LDH and AST concentrations did not change significantly. ② serum CK concentration in the heart of the irradiated area accounted for more than 50% of the heart area, and radiation doses higher than 60Gy increased. ③ serum CK-MB concentration in the heart affected area accounted for more than 50% of the heart area increased. ④ There are 2 cases of ECG ST segment changes, accounting for 2.3% of all cases. Conclusion: The change of serum CK concentration is related to the area of the heart affected by irradiation dose and the change of serum CK-MB concentration is only related to the irradiated area of the heart.