难治性肾病综合征 (ｒｅｆｒａｃｔｏｒｙｎｅｐｈｒｏｐａｔｈｙｓｙｎｄｒｏｍｅ,ＲＮＳ)的治疗是临床医师经常遇到的棘手问题。我科自 2 0世纪 80年代初率先报道在肾病领域使用雷公藤〔1,2〕,迄今已近 2 0年。多年来 ,我科先后经历肾炎合剂 (Ⅰ号 )、肾炎合剂Ⅱ号及肾炎灵颗 The treatment of refractory nephrotic syndrome (RNS) is a thorny problem often encountered by clinicians. Our department from the early 1980s first reported the use of triptolide in the field of kidney disease [1,2], so far nearly 20 years. Over the years, our department has experienced nephritis mixture (Ⅰ), nephritis mixture Ⅱ and nephritis spirit