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目的了解南京市秦淮区高中一年级及初中一年级乙肝病毒表面抗原携带状况、评价1992年乙肝疫苗纳入计划免疫管理后的免疫效果。方法对两个年级学生采集3ml静脉血分离血清,采用酶联免疫吸附法(ELISA)检测HBsAg、抗-HBs、抗-HBc、HBeAg、抗-HBe。率的比较采用χ2检验,P<0.05为差异有统计学意义。结果 HBsAg总阳性率为1.10%,男女分别为0.66%和1.46%,差异无统计学意义。单抗-HBs阳性率为34.51%,高中及初中年级组分别为28.71%和43.76%,差异有统计学意义。结论乙肝疫苗纳入计划免疫管理17年以来,乙肝病毒表面抗原阳性率已降到较低水平,随着年龄的增加单抗-HBs阳性率逐渐下降,且下降较明显,应及时进行加强免疫。
Objective To understand the carrying status of hepatitis B virus surface antigen in the first grade and the first grade of senior high school in Qinhuai District of Nanjing and evaluate the immune effect of administering hepatitis B vaccine in 1992 after planned immunization management. Methods Three sera of venous blood were collected from two grades of students, and HBsAg, anti-HBs, anti-HBc, HBeAg and anti-HBe were detected by enzyme-linked immunosorbent assay (ELISA) Rate comparison using χ2 test, P <0.05 for the difference was statistically significant. Results The overall positive rate of HBsAg was 1.10%, with a difference of 0.66% and 1.46% for men and women respectively, with no significant difference. The positive rate of monoclonal antibody-HBs was 34.51%, and the high school and junior middle school were 28.71% and 43.76% respectively, the difference was statistically significant. Conclusions The positive rate of hepatitis B virus surface antigen has dropped to a lower level after 17 years of planned immune administration. With the increase of age, the positive rate of monoclonal antibody-HBs gradually decreased, and the decrease was obvious. Therefore, it should be promptly boosted.