产前筛查和产前诊断是降低新生儿出生缺陷率的主要手段 ,本研究利用B超结合生化指标产前筛查缺陷儿 ,并进行随访。结果检出不良妊娠 8例 ,占整个异常妊娠的 6 1.5 2 % ( 8/13)。这次随访中 ,总的不良妊娠率 2 4.5 3 % ( 13/5 30 ) ,B超查出 7.5 5‰ ( 4/5 30 )的异常妊娠。有 7例异常妊娠者出现αFP和HCG的异常 ,占生化筛查的 14.46‰ ( 7/4 84)。由此看出 ,利用B超结合生化指标产前筛查缺陷儿是十分必要和有效的 Prenatal screening and prenatal diagnosis are the primary means to reduce the birth defect rate in newborns. In this study, B-ultrasound and biochemical markers were used to screen for prenatal defects and were followed up. Results 8 cases of adverse pregnancy were detected, accounting for 6 1.52% (8/13) of the total abnormal pregnancy. In this follow-up, the total adverse pregnancy rate was 4.53% (13/5 30), while the abnormal ultrasound pregnancy rate was 7.5 5% (4/5 30). Abnormalities of αFP and HCG occurred in 7 cases of abnormal pregnancy, accounting for 14.46 ‰ (7/4 84) in biochemical screening. This shows that the use of B-biochemical indicators of prenatal screening for defective children is very necessary and effective