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一般认为,小鼠腹腔感染是类似于人的较好实验模型之一。作者用对哌拉西林耐药并能产生β-内酰胺酶的脆弱拟杆菌,以及对哌拉西林敏感的粪埃希氏菌制成非致死性腹腔感染模型,探讨哌拉西林与β-内酰胺酶抑制剂Tazobactam合剂(YP-14)的效果。材料和方法试菌为脆弱拟杆菌10-20和粪埃希氏菌K-1。哌拉西林和YP-14(哌拉西林与Tazobactam之比为4:1)对脆弱拟杆
It is generally accepted that intraperitoneal infection in mice is one of the better experimental models similar to humans. The authors made a non-lethal intraperitoneal infection model with Bacteroides fragilis that is resistant to piperacillin and produces β-lactamase, and piperacillin-susceptible Escherichia coli to explore the relationship between piperacillin and β-endo Effect of the amidase inhibitor Tazobactam cocktail (YP-14). Materials and Methods The test bacteria were Bacteroides fragilis 10-20 and Escherichia coli K-1. Piperacillin and YP-14 (piperacillin to Tazobactam ratio of 4: 1) to fragile rod