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目的 了解医院革兰氏阴性杆菌流行分布与耐药性。方法 采用细菌鉴定与药敏系统监测464株革兰氏阴性杆菌的耐药性。结果 464株革兰氏阴性杆菌中以铜绿假单胞菌(29.3％)和大肠杆菌(23.3％)最多见;革兰氏阴性杆菌耐药率最低的抗生素为亚胺培南(25.0％),其次为阿米卡星(49.6％)、庆大霉素(58.4％)、妥布霉素(53.9％)和环丙沙星(55.0％)。结论 临床医生应当高度重视细菌耐药问题,及时掌握病原菌的流行分布与敏感模式,合理使用抗生素。
Objective To understand the prevalence and drug resistance of Gram-negative bacilli in hospitals. Methods 464 Gram-negative bacilli were tested for drug resistance by bacterial identification and susceptibility testing. Results Among the 464 Gram-negative bacilli, Pseudomonas aeruginosa (29.3%) and Escherichia coli (23.3%) were the most common. The antibiotics with the lowest gram-negative bacilli resistance were imipenem (25.0%), Followed by amikacin (49.6%), gentamicin (58.4%), tobramycin (53.9%) and ciprofloxacin (55.0%). Conclusion Clinicians should attach great importance to the issue of bacterial resistance, timely grasp of the epidemic distribution and sensitive patterns of pathogens, rational use of antibiotics.