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目的探讨尘肺合并严重肺间质纤维化患者的无创机械通气治疗康复效果。方法将40例尘肺合并严重肺间质纤维化患者分成无创机械通气治疗组(20例)和一般对照组(20例)。治疗组除采用常规临床治疗外,均给予无创机械通气;对照组采用内科常规用药。治疗前后2组均采用BODE评分评定患者康复情况。同时采用生存质量评定(QOL)量表评定患者的治疗效果。结果治疗前2组的BODE评分和QOL评定差异均无统计学意义(P>0.05)。治疗3个月后,治疗组的BODE评分明显降低,QOL评分有明显改善,与治疗前比较,差异均有统计学意义(P<0.01)。结论尘肺合并严重肺间质纤维化患者采用无创机械通气治疗,能显著降低患者的BODE评分,改善尘肺患者的呼吸困难症状,提高生存质量、运动耐力及改善患者的生活质量评分(ADL)水平。
Objective To investigate the effect of noninvasive mechanical ventilation in patients with pneumoconiosis and severe pulmonary fibrosis. Methods Forty patients with pneumoconiosis and severe pulmonary fibrosis were divided into non-invasive mechanical ventilation group (n = 20) and general control group (n = 20). In addition to the treatment group with conventional clinical treatment, were given non-invasive mechanical ventilation; control group using conventional medicine. Before and after treatment, the BODE score was used to evaluate the rehabilitation of patients in both groups. The quality of life assessment (QOL) scale was also used to evaluate the therapeutic effect of the patients. Results There was no significant difference in BODE score and QOL between the two groups before treatment (P> 0.05). After 3 months of treatment, the BODE score of the treatment group decreased significantly, QOL score improved significantly, with statistical significance (P <0.01). Conclusion Noninvasive mechanical ventilation can reduce the BODE score of patients with pneumoconiosis and severe pulmonary fibrosis, improve the symptoms of dyspnea, improve the quality of life, exercise endurance and improve the quality of life (ADL) of patients with pneumoconiosis.