【摘 要】
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Dear Editor,rnApproximately 20％ of men with nonobstructive azoospermia (NOA) are diagnosed with infertility caused by genetic defects. These include chromosomal abnormalities, Y-chromosome microdeletions, and several specific gene mutations/deletions, suc
【机 构】
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Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa 078-8510, Japan;Dep
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Dear Editor,rnApproximately 20％ of men with nonobstructive azoospermia (NOA) are diagnosed with infertility caused by genetic defects. These include chromosomal abnormalities, Y-chromosome microdeletions, and several specific gene mutations/deletions, such as in DAZ, RBMY, USP9Y, SYCP3, HSF2, PLK4, and TEX11. Several histones have been detected in mammalian testes, and testis-specific variants are specifically and highly expressed during spermatogenesis. Recently, histone H3 variants of human and mouse genomes have been identified by in silico hybridization screening. The mouse H3t histone has a human counterpart, H3T (H3.4), and shares a common chaperon recognition motif with H3.1 and H3.2.
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