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微小RNA(miRNA)是一类进化上高度保守的、内源性的非编码小分子单链RNA,它通过与靶基因相互作用来降解靶mRNA或抑制靶基因的翻译,从而进行转录后的表达调控[1]。Lee等[2]和Reinhart等[3]分别在线虫中发现了能调控胚胎后期发育的小分子RNA lin-4和具有转录后调节功能的小分子
MicroRNAs (miRNAs) are a class of phylogenetically conserved, endogenous, non-coding small molecule single-stranded RNAs that act by interacting with target genes to degrade target mRNAs or inhibit the translation of target genes for post-transcriptional expression Regulation [1]. Lee et al. [2] and Reinhart et al [3] found a small molecule RNA lin-4 and a post-transcriptional regulatory small molecule that can regulate late embryonic development in nematodes