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目的探究氟伐他汀联合贝那普利对老年心力衰竭(HF)患者心功能、血浆N-末端脑钠肽(NT-Pro BNP)及超敏C反应蛋白(Hs-CRP)水平的影响。方法选取漯河市郾城区人民医院2014年4月—2016年3月收治的98例HF老年患者,依据随机数表法分为两组,各49例。对照组予以贝那普利治疗,观察组予以贝那普利与氟伐他汀联合治疗。统计两组临床效果,并对比治疗前后两组心功能指标[短轴缩短率(FS)、左室射血分数(LVEF)]、Hs-CRP、NT-Pro BNP水平变化情况。结果两组临床总有效率对比,观察组95.92%(47/49)远高于对照组81.63%(40/49),差异有统计学意义(P<0.05);治疗后,与对照组相比,联合组FS、LVEF水平较高,差异有统计学意义(P<0.05);治疗后,与对照组相比,观察组FS、LVEF水平较高,LVEDD水平较低,差异有统计学意义(P<0.05)。结论对HF老年患者予以贝那普利与氟伐他汀联合治疗,效果更为显著,可明显降低炎性因子及NT-Pro BNP水平,有效改善心功能。
Objective To investigate the effects of fluvastatin combined with benazepril on cardiac function, plasma NT-Pro BNP and Hs-CRP levels in elderly patients with heart failure (HF). Methods A total of 98 elderly patients with HF admitted from April 2014 to March 2016 in Luohe City People’s Hospital were divided into two groups according to the random number table (49 cases). The control group was treated with benazepril, and the observation group was treated with benazepril and fluvastatin. The clinical effects were compared between the two groups. The changes of cardiac function indexes (short axis shortening (FV), left ventricular ejection fraction (LVEF)], Hs-CRP and NT-Pro BNP were compared before and after treatment. Results The total effective rate of the two groups was 95.92% (47/49) in the observation group, which was significantly higher than that in the control group (81.63%, 40/49) (P <0.05). After treatment, compared with the control group (P <0.05). Compared with the control group, the levels of FS and LVEF in the observation group were higher and the LVEDD level was lower, the difference was statistically significant (P < P <0.05). Conclusions The combined treatment of benazepril and fluvastatin in elderly patients with HF is more effective and can significantly reduce the levels of inflammatory cytokines and NT-Pro BNP and improve cardiac function.