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本文用含β-VLDL 的培养基体外培养小白鼠腹腔巨噬细胞,结果表明:β-VLDL 使细胞内胆固醇酯含量增加10倍;使胞内 ACAT 活性增加5倍.此提示β-VLDL 与动脉粥样硬化中泡沫细胞的形成密切相关.
In this study, the peritoneal macrophages of mice were cultured in vitro with β-VLDL. The results showed thatβ-VLDL increased the intracellular cholesterol ester content by 10-fold and the intracellular ACAT activity by 5-fold, suggesting that β-VLDL interacts with arteries The formation of foam cells in atherosclerosis is closely related.