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目的 研究肾综合征出血热 (HFRS)病毒宫内感染情况及其对婴儿的影响。方法 对妊娠期感染HFRS病毒者 ,于其分娩时留取母血和脐带血进行抗 HFRSIgG检测 ,同时对顺产新生儿采取静脉血进行抗 HFRSIgM检测 ,并应用血凝抑制试验 (HI)对HFRS病毒进行分型 ,另外对顺产的新生儿进行全面查体和定期随访观察。结果 母血抗 HFRSIgG均阳性 ,死胎的 2 7例脐带血抗 HFRSIgG阳性 2 3例 ,孕妇痊愈后自然分娩的 12例中脐带血和静脉血有 2例抗 HFRSIgG阳性 ,而抗 HFRSIgM阴性。并发现 14例顺产新生儿生长发育全部正常。结论 HFRS病毒存在宫内感染 ,并易致死胎 ,但对顺产婴儿未发现致畸作用。
Objective To study the intrauterine infection of hemorrhagic fever with renal syndrome (HFRS) virus and its impact on infants. Methods The HFRSV infected during pregnancy were collected for maternal blood and umbilical cord blood at the time of delivery for detection of anti-HFRSIgG. At the same time, the newborn infants were treated with anti-HFRSIgM by venous blood. The hemagglutination inhibition (HI) For type, in addition to a full range of newborns on the delivery and regular follow-up observation. Results The positive rate of HFRSIgG in maternal blood was positive. The positive rate of HFRSIgG in 27 cases of stillbirth was 23 cases of HFRSIgG positive. In 12 cases of spontaneous delivery after pregnant women recovered, 2 cases were positive for HFRSIgG and negative for HFRSIgM in both umbilical cord blood and venous blood. And found that 14 cases of all newborns with normal growth and development. Conclusion The HFRS virus has intrauterine infection and is prone to cause fetal death, but no teratogenic effects are found on the fetus.