目前,机械通气已经成为抢救危重病人最重要的手段之一,随着机械通气的广泛应用,机械通气致肺损伤(VILI)的发生率也逐渐增高。对VILI损伤机制的研究经历了气压伤、容积伤、剪切伤和生物伤等几个阶段。通常认为,机械通气导致VILI是多种损伤机制综合作用的结果,而非某一种损伤作用 At present, mechanical ventilation has become one of the most important means of rescuing critically ill patients. With the widespread use of mechanical ventilation, the incidence of ventilatory-induced lung injury (VILI) also gradually increased. The research on the mechanism of VILI injury has experienced several stages of barotrauma, volume wound, shear injury and biological injury. It is generally accepted that mechanical ventilation leads to VILI as a combined result of multiple mechanisms of injury rather than a specific lesion