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.Objective:The purpose of this paper was to study the expression levels of newly described lymphatic endothelial markers – LYVE-1,Prox-1,podoplanin and 5'-nucleotidase,and their correlation with metastasis of human colorectal cancers.Methods:Tumor and corresponding tumor-side normal tissue samples were obtained from resected specimens immediately after operation.Expression level of each factor was determined by quantitative real-time PCR (RT-PCR) and Western blot technique.Results:Expression levels of lymphatic endothelial markers LYVE-1,Prox-1,podoplanin and 5'-nucleotidase were significantly different in tumor and tumor-side normal groups.Expression levels of Prox-1 and podoplanin were higher in patients with positive lymph node metastasis than those without metastasis.LYVE-1,but not 5'-nucleotidase expression level was higher in both cancer and normal groups.Conclusion:These results indicate that combined quantitative analysis of lymphangiogenic markers LYVE-1,Prox-1 and podoplanin in colorectal cancer specimens may be useful in predicting metas-tasis of colorectal cancer to regional lymph nodes.However,the role of 5'-nucleotidase in predicting metastasis of colorectal cancer still remains to be further analyzed.