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目的观察热毒宁注射液联合单磷酸阿糖腺苷治疗小儿疱疹性口腔炎的效果。方法选择2008年6月—2013年6月收治的疱疹性口腔炎患儿120例,随机分为对照组与观察组各60例。对照组静脉滴注单磷酸阿糖腺苷,每次5~10mg/kg,1次/d;观察组在对照组基础上静脉滴注热毒宁注射液,每次0.5~0.8 ml/kg,1次/d。两组均持续治疗3~5 d。比较两组疗效、退热时间、疱疹消失时间及不良反应。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果对照组总有效率为76.67%,观察组为93.33%,两组比较差异有统计学意义(χ2=6.536,P<0.05)。对照组退热时间、疱疹消失时间分别为(2.66±1.57)、(5.21±2.20)d,观察组分别为(1.62±0.87)、(2.30±1.70)d,两组比较差异均有统计学意义(t=4.488、8.107,均P<0.05)。两组均未见明显不良反应。结论热毒宁注射液联合单磷酸阿糖腺苷治疗小儿疱疹性口腔炎效果显著,安全性高,具有较高的临床应用价值。
Objective To observe the effect of Renduining injection combined with adenosine monophosphate in the treatment of pediatric herpetic stomatitis. Methods 120 cases of herpes stomatitis admitted in our hospital from June 2008 to June 2013 were randomly divided into control group and observation group with 60 cases each. Control group intravenous drip of monophosphate phosphoramidite, each 5 ~ 10mg / kg, 1 / d; the observation group in the control group on the basis of intravenous injection of intravenous injection of Renduvin 0.5 ~ 0.8 ml / kg, 1 time / d. Both groups continued treatment for 3 ~ 5 days. The curative effect, antipyretic time, disappearance of herpes and adverse reactions were compared between the two groups. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 76.67% in the control group and 93.33% in the observation group. The difference between the two groups was statistically significant (χ2 = 6.536, P <0.05). The time of fever and disappearance of herpes in control group were (2.66 ± 1.57) and (5.21 ± 2.20) days, respectively, and the difference was statistically significant between the two groups (1.62 ± 0.87 and 2.30 ± 1.70) days (t = 4.488,8.107, all P <0.05). No obvious adverse reactions were found in both groups. Conclusion Reveduning injection combined with vidarabine monotherapy for the treatment of pediatric herpetic stomatitis has obvious effect, high safety and high clinical value.