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目的:比较静脉应用胺碘酮与毛花苷治疗充血性心力衰竭(CHF)伴快速心室率心房颤动(Af)患者的短时疗效。方法:60例CHF伴快速心室率Af患者,随机分为胺碘酮组30例、毛花苷组30例,在常规治疗基础上,两组分别静脉应用胺碘酮及毛花苷,观察用药后不同时刻的心室率变化、药物平均起效时间及不良反应。结果:两组患者用药后心室率均明显下降。与用药前比较均有统计学差异,用药2h后胺碘酮组心室率下降幅度明显大于毛花苷组(P<0.05);胺碘酮、毛花苷组平均起效时间分别为(26．5±12.7)min和(48.9±14.2)min(P<0．01);胺碘酮、毛花苷组治疗总有效率分别为80.0%和70.0%(P> 0.05)。结论:静脉应用胺碘酮治疗CHF伴快速心室率Af短时效果显著,患者安全性好。
OBJECTIVE: To compare the short-term efficacy of intravenous amiodarone and lanosine in the treatment of patients with rapid ventricular fibrillation (AF) with congestive heart failure (CHF). Methods: Sixty CHF patients with fast ventricular rate Af were randomly divided into amiodarone group (n = 30) and curcumin group (n = 30). On the basis of conventional treatment, amiodarone and lanoside were administered intravenously in both groups. Ventricular rate changes at different times, the average onset time of drugs and adverse reactions. Results: After treatment, the ventricular rate was significantly decreased in both groups. Compared with the pre-treatment, there was a significant difference between the two groups. After 2-hour administration, the decrease of ventricular rate in amiodarone group was significantly greater than that in gliposide group (P <0.05). The mean onset time of amiodarone and gloction group was (26. 5 ± 12.7) min and (48.9 ± 14.2) min respectively (P <0.01). The total effective rates of amiodarone and lanolin group were 80.0% and 70.0%, respectively (P> 0.05). Conclusion: Intravenous amiodarone treatment of CHF with rapid ventricular rate Af short-term effect is significant, patients with good safety.