2-Alkyl-3-hydroxyl piperidine is a structural unit found in numerous bioactive natural products, drugs and drug candidates. For example, (+)-L-733 060 (1)1 and
Polyhydroxylated indolizidine alkaloids, such as castanospermine (Ⅰ) and swainsonine (H)are of longstanding interest due to their powerful glycosidase inhibito