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目的观察兰索拉唑与生长抑素联合应用对急性上消化道大出血的治疗效果,探讨两者联合应用的临床价值。方法将急诊内科收治60例急性上消化道大出血患者随机分为2组,治疗组30例,对照组30例。治疗组给予兰索拉唑与生长抑素联合应用,兰索拉唑30 mg加入生理盐水100 ml静脉滴注,每天2次,生长抑素开始以250μg静脉推注,随之以250μg/h微量泵持续泵入,疗程为72 h;对照组给予兰索拉唑应用,兰索拉唑30 mg加入生理盐水100 ml静脉滴注,每天2次,疗程为72 h;连续用药72 h后分别观察治疗组与观察组止血成功例数(显效例数+有效例数)及无效例数,根据计数资料(率)及χ2检验以判定临床疗效。结果治疗组止血显效19例,有效10例,无效1例,总有效率为96.67%(29/30);对照组止血显效15例,有效7例,无效8例,总有效率为73.33%(22/30);治疗组疗效明显优于观察组,差异有统计学意义(χ2=6.444,P<0.05)。结论兰索拉唑联合生长抑素应用治疗急性上消化道大出血可明显提高止血成功率,具有良好的临床应用价值,值得临床推广应用。
Objective To observe the therapeutic effect of lansoprazole combined with somatostatin on acute upper gastrointestinal bleeding and to explore the clinical value of combination of both. Methods A total of 60 cases of acute upper gastrointestinal bleeding in emergency department were randomly divided into 2 groups: 30 cases in the treatment group and 30 cases in the control group. The treatment group was given lansoprazole combined with somatostatin, lansoprazole 30 mg by adding saline 100 ml intravenous infusion twice daily, somatostatin 250μg intravenous injection, followed by 250μg / h trace Pump continuous pump, treatment for 72 h; control group given lansoprazole application, lansoprazole 30 mg by adding saline 100 ml intravenous infusion twice daily for 72 hours; 72 hours after continuous administration were observed The number of successful hemostasis (effective cases + effective cases) and invalid cases in the treatment group and the observation group were determined according to the count data (rate) and χ2 test to determine the clinical efficacy. Results In the treatment group, 19 cases were markedly effective in hemostasis, 10 cases were effective and 1 case was ineffective. The total effective rate was 96.67% (29/30). In the control group, 15 cases were effective in hemostasis, 7 cases were effective and 8 cases were ineffective. The total effective rate was 73.33% 22/30). The curative effect in the treatment group was significantly better than that in the observation group (χ2 = 6.444, P <0.05). Conclusion The combination of lansoprazole and somatostatin in the treatment of acute upper gastrointestinal bleeding can significantly improve the success rate of hemostasis, has good clinical value, worthy of clinical application.